{"id":165,"date":"2025-07-13T12:22:23","date_gmt":"2025-07-13T12:22:23","guid":{"rendered":"https:\/\/oralpathology.hiroshima-u.ac.jp\/?page_id=165"},"modified":"2025-07-28T13:14:19","modified_gmt":"2025-07-28T13:14:19","slug":"publication-jp","status":"publish","type":"page","link":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/publication-jp\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"165\" class=\"elementor elementor-165\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6a785dc e-flex e-con-boxed e-con e-parent\" data-id=\"6a785dc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5229db3 elementor-widget elementor-widget-heading\" data-id=\"5229db3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d81447c e-flex e-con-boxed e-con e-parent\" data-id=\"d81447c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03d64d1 e-con-full e-flex e-con e-child\" data-id=\"03d64d1\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-84fc846 elementor-widget elementor-widget-image\" data-id=\"84fc846\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"567\" height=\"430\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4.jpg\" class=\"attachment-large size-large wp-image-180\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4.jpg 567w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4-300x228.jpg 300w\" sizes=\"(max-width: 567px) 100vw, 567px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26d8abf e-con-full e-flex e-con e-child\" data-id=\"26d8abf\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4d69a0d e-con-full e-flex e-con e-child\" data-id=\"4d69a0d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a99b18f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"a99b18f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasion. Ando T (corresponding author), Okamoto K, Sato K, Goto Y, Izumi H, Kataoka N, Ueda Y, Iglesias-Bartolome R, Yoshimoto T, Shintani T, Yanamoto S, Miyauchi M, Gutkind JS, Kajiya M. preprint, 2025. <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-030f17c elementor-widget elementor-widget-text-editor\" data-id=\"030f17c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u304c\u3093\u306f\u5897\u6b96\u80fd\u3092\u9ad8\u3081\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5468\u56f2\u306e\u514d\u75ab\u7d30\u80de\u304b\u3089\u306e\u653b\u6483\u3092\u9003\u308c\u3066\u5897\u6b96\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3068\u8a00\u3044\u307e\u3059\u3002\u3000\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3068\u3057\u3066\u81e8\u5e8a\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<span style=\"text-wrap-mode: initial;\">\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066YAP\/TAZ\u306f\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3057\u3066\u304a\u308a\u3001\u5897\u6b96\u30fb\u85ac\u5264\u8010\u6027\u306b\u91cd\u8981\u306a\u3053\u3068\u306f\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u514d\u75ab\u56de\u907f\u306b\u95a2\u9023\u3059\u308b\u304b\u306f\u672a\u89e3\u660e\u3067\u3057\u305f\u3002<\/span><\/h4><h4>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001Hippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3059\u308b\u60a3\u8005\u304c\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u594f\u529f\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u4e00\u56e0\u3068\u3057\u3066\u3001YAP\/TAZ\u6d3b\u6027\u5316\u306f\u5206\u5316\u306e\u4f4e\u4e0b\u3068\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u6027\u4ea2\u9032\u3092\u793a\u3057\u3001\u7d50\u679c\u7684\u306b\u907a\u4f1d\u5b50\u5909\u7570\u91cf\uff08TMB\uff09\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u5468\u56f2\u306b\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u304c\u30ea\u30af\u30eb\u30fc\u30c8\u3055\u308c\u3066\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001YAP\/TAZ\u6d3b\u6027\u5316\u306f\u3001BRD4\u3068\u5171\u306bsuper enhancer\u306e\u5f62\u6210\u3092\u4ecb\u3057\u3066PD-L2\u306e\u767a\u73fe\u91cf\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3001\u514d\u75ab\u56de\u907f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u6a5f\u69cb\u304c\u3001\u7d50\u679c\u7684\u306b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3078\u306e\u611f\u53d7\u6027\u3092\u4ea2\u9032\u3055\u305b\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/h4><h4>\u3000\u4eca\u5f8c\u3001\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306b\u5bfe\u3059\u308bYAP\/TAZ\u6d3b\u6027\u5316\u306e\u5f71\u97ff\u3092\u89e3\u660e\u3057\u3066\u3044\u304f\u3068\u3068\u3082\u306b\u3001PD-L2\u3084YAP\/TAZ\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u305f\u306a\u5275\u85ac\u958b\u767a\u30fb\u6cbb\u7642\u6cd5\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/www.researchsquare.com\/article\/rs-4330731\/v1\" target=\"_blank\" rel=\"noopener\">\u8ad6\u6587\u306f\u3053\u3061\u3089<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-397e260 e-flex e-con-boxed e-con e-parent\" data-id=\"397e260\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c9bac2e e-con-full e-flex e-con e-child\" data-id=\"c9bac2e\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-55a8063 e-con-full e-flex e-con e-child\" data-id=\"55a8063\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b59118 elementor-widget elementor-widget-heading\" data-id=\"7b59118\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">YAP\/TAZ interacts with RBM39 to confer resistance against indisulam. Ando T (corresponding author), Okamoto K, Ueda Y, Kataoka N, Shintani T, Yanamoto S, Miyauchi M, Kajiya M. Oncogenesis, 13(1):25, 2024<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1cd19aa elementor-widget elementor-widget-text-editor\" data-id=\"1cd19aa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066YAP\/TAZ\u306f\u6d3b\u6027\u5316\u3057\u3066\u304a\u308a\u3001\u3000\u6838\u5185\u79fb\u884c\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6838\u5185\u306b\u304a\u3044\u3066YAP\/TAZ\u304c\u3069\u306e\u3088\u3046\u306a\u56e0\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u304b\u3001\u305d\u306e\u5168\u8c8c\u306f\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u672c\u7814\u7a76\u3067\u306fYAP\u306e\u65b0\u305f\u306a\u6838\u5185\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u3092\u63a2\u7d22\u3057\u3001RBM39\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/h4><h4>\u3000RBM39\u306fRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u8ee2\u5199\u56e0\u5b50\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u4ea2\u9032\u3057\u3001\u307e\u305fmRNA\u306e\u6b63\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002Indisulam\u306f\u30a2\u30ea\u30eb\u30b9\u30eb\u30db\u30f3\u30a2\u30df\u30c9\u306e\u4e00\u3064\u3067\u3059\u3002Indisulam\u306fRBM39\u3092\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u306b\u7d50\u5408\u3055\u305b\u3066\u3001\u5206\u89e3\u3055\u305b\u307e\u3059\u3002\u305d\u308c\u3086\u3048\u306b\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u751f\u3058\u3001\u7d30\u80de\u6b7b\u306b\u81f3\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u81e8\u5e8a\u6cbb\u9a13\u306b\u304a\u3044\u3066\u306f\u671f\u5f85\u307b\u3069\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u305a\u3001\u8010\u6027\u6a5f\u69cb\u306e\u89e3\u660e\u304c\u671b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001Indisulam\u306f\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u306e\u7523\u751f\u3082\u4fc3\u3057\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306a\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3084\u306f\u308a\u8010\u6027\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u306a\u3044\u9650\u308a\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3068\u306e\u4f75\u7528\u52b9\u679c\u3082\u9650\u5c40\u7684\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/h4><h4>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001YAP\u304cRBM39\u306b\u7d50\u5408\u3057\u30011) YAP\/TAZ\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u3059\u3053\u3068\u30012) indisulam\u306b\u3088\u308bRBM39\u306e\u5206\u89e3\u3092\u59a8\u3052\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002YAP\/TAZ\u306e\u6d3b\u6027\u5316\u306fintegrin\/collagen\u306e\u7523\u751f\u3092\u4fc3\u3057\u3066FAK\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u307e\u305f\u7d30\u80de\u5468\u671f\u3084DNA\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3082\u963b\u5bb3\u3067\u304d\u308b\u305f\u3081\u3001indisulam\u3078\u306e\u8010\u6027\u3092\u4ed8\u4e0e\u3059\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/h4><h4>\u3000\u591a\u304f\u306e\u56fa\u5f62\u304c\u3093\u3067YAP\/TAZ\u306e\u6d3b\u6027\u5316\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001Indisulam\u304c\u6cbb\u9a13\u3067\u594f\u529f\u3057\u306b\u304f\u304b\u3063\u305f\u7406\u7531\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066RBM39\u3068YAP\/TAZ\u76f8\u4e92\u4f5c\u7528\u3092\u56de\u907f\u3067\u304d\u308b\u3088\u3046\u306a\u65b0\u305f\u306a\u5275\u85ac\u306e\u958b\u767a\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s41389-024-00527-0\" target=\"_blank\" rel=\"noopener\">DOI: 10.1038\/s41389-024-00527-0<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d332071 elementor-widget elementor-widget-image\" data-id=\"d332071\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"520\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-1024x520.jpg\" class=\"attachment-large size-large wp-image-177\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-1024x520.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-300x152.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-768x390.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64.jpg 1055w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e15ef35 e-flex e-con-boxed e-con e-parent\" data-id=\"e15ef35\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4344279 e-con-full e-flex e-con e-child\" data-id=\"4344279\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e438aac elementor-widget elementor-widget-image\" data-id=\"e438aac\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"513\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1024x513.jpg\" class=\"attachment-large size-large wp-image-176\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1024x513.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-300x150.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-768x385.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1536x770.jpg 1536w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96.jpg 2000w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2234010 e-con-full e-flex e-con e-child\" data-id=\"2234010\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4303de4 e-con-full e-flex e-con e-child\" data-id=\"4303de4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c265d25 elementor-widget elementor-widget-heading\" data-id=\"c265d25\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">AXL activates YAP through the EGFR\u2013LATS1\/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, Okamoto K, Ando T (corresponding author), Izumi H, Kobayashi SS, Shintani T, Gutkind JS, Yanamoto S, Miyauchi M, Kajiya M. Oncogene, 42:2869-2877, 2023.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e46376 elementor-widget elementor-widget-text-editor\" data-id=\"3e46376\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u53d7\u5bb9\u4f53\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306eEGFR\u306fYAP\u3092\u6d3b\u6027\u5316\u3055\u305b<span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u307e\u3059\u304c\u3001EGFR\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u304c\u9650\u5b9a\u7684\u306a\u306e\u306f\u306a\u305c\u3067\u3057\u3087<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3046\u304b\u3002EGFR\u963b\u5bb3\u85ac\u306b\u8010\u6027\u3092\u793a\u3059\u75c7\u4f8b\u3067YAP\u306e\u518d\u6d3b\u6027\u5316\u304c<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u751f\u3058\u308b\u3053\u3068\u304b\u3089\u3001\u5225\u306e\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304c\u95a2\u4e0e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u89e3\u6790\u304b\u3089\u65b0\u305f\u306bAXL<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002AXL\u306fEGFR\u3068\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">EGFR-LATS1\/2\u3092\u4ecb\u3057\u3066YAP\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u6a5f\u69cb\u3092\u660e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">EGFR\u963b\u5bb3\u85ac\u306e\u8010\u6027\u3092\u89e3\u9664\u3059\u308b\u305f\u3081\u3001<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">AXL\u963b\u5bb3\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3057\u305f\u3002<\/span><\/h4><h4>\u3000EGFR\u963b\u5bb3\u85ac\u3068AXL\u963b\u5bb3\u85ac\u306e\u4f75\u7528\u3001\u3042\u308b\u3044\u306f\u65b0\u305f\u306a\u6cbb<span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u7642\u6226\u7565\u306e\u958b\u767a\u304c\u4eca\u5f8c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/span><\/h4><h4>Readers\u00a0Choice: The best of Oncogene 2023\u306b\u9078\u3070\u308c\u307e\u3057\u305f\uff082024\u5e741\u67089\u65e5\uff09\uff01<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s41388-023-02810-7\" target=\"_blank\" rel=\"noopener\">DOI: 10.1038\/s41388-023-02810-7<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a1bc7d e-flex e-con-boxed e-con e-parent\" data-id=\"6a1bc7d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b2d382a e-con-full e-flex e-con e-child\" data-id=\"b2d382a\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-244b563 e-con-full e-flex e-con e-child\" data-id=\"244b563\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f446f8 elementor-widget elementor-widget-heading\" data-id=\"8f446f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS. Communications Biology, 4:1237, 2021.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f9ac38 elementor-widget elementor-widget-text-editor\" data-id=\"5f9ac38\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"font-weight: 400;\">\u53d7\u5bb9\u4f53\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306eEGFR\u306f\u30ea\u30ac\u30f3\u30c9EGF\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3057\u3001\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u5897\u6b96\u3092\u4fc3\u3057\u307e\u3059\u3002\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u306f\u907a\u4f1d\u5b50\u5897\u5e45\u30fb\u904e\u5270\u767a\u73fe\u3057\u3001\u80ba\u817a\u764c\u3067\u306f\u304a\u3088\u305d50%\u304c\u6d3b\u6027\u5316\u5909\u7570\u3092\u793a\u3057\u307e\u3059\u3002EGFR\u3068YAP\/TAZ\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u8a73\u7d30\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u672c\u8ad6\u6587\u3067\u306f\u3001EGFR\u304cHippo\u69cb\u6210\u8981\u7d20\u306e\u4e00\u3064\u3067\u3042\u308b<\/h4><h4 style=\"font-weight: 400;\">MOB1\u306e3\u7b87\u6240\u306e\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u306e\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u3059\u3053\u3068\u3067\u3001LATS1\/2\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001YAP\/TAZ\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u3059\u6a5f\u69cb\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/h4><h4 style=\"font-weight: 400;\">\u3000\u6b74\u53f2\u7684\u306b\u6614\u304b\u3089\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u305fEGFR\u304c\u3001\u307e\u3060\u767a\u898b\u3055\u308c\u3066\u304b\u3089\u6b74\u53f2\u7684\u306b\u6d45\u3044\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3067\u3042\u308bHippo\u7d4c\u8def\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u70b9\u304c\u4eca\u56de\u306e\u30b7\u30b0\u30ca\u30eb\u7814\u7a76\u3068\u3057\u3066\u306e\u9762\u767d\u3055\u3068\u30a4\u30f3\u30d1\u30af\u30c8\u306e\u5927\u304d\u3055\u3092\u8c61\u5fb4\u3057\u3066\u3044\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s42003-021-02744-4\">DOI: 10.1038\/s42003-021-02744-4<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-164a71a elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"164a71a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"346\" height=\"222\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2.jpg\" class=\"attachment-large size-large wp-image-179\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2.jpg 346w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2-300x192.jpg 300w\" sizes=\"(max-width: 346px) 100vw, 346px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09 Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasion. A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-165","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/comments?post=165"}],"version-history":[{"count":41,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165\/revisions"}],"predecessor-version":[{"id":652,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165\/revisions\/652"}],"wp:attachment":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/media?parent=165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}