{"id":165,"date":"2025-07-13T12:22:23","date_gmt":"2025-07-13T12:22:23","guid":{"rendered":"https:\/\/oralpathology.hiroshima-u.ac.jp\/?page_id=165"},"modified":"2026-10-31T05:46:57","modified_gmt":"2026-10-31T05:46:57","slug":"publication-jp","status":"publish","type":"page","link":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/publication-jp\/","title":{"rendered":"\u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"165\" class=\"elementor elementor-165\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7f00f5 e-flex e-con-boxed e-con e-parent\" data-id=\"e7f00f5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-76314a1 elementor-widget elementor-widget-text-editor\" data-id=\"76314a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u7814\u7a76\u5ba4\u306e\u5168\u3066\u306e\u8ad6\u6587\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u306e\u30ea\u30f3\u30af\u304b\u3089\u3054\u78ba\u8a8d\u3044\u305f\u3060\u3051\u307e\u3059\u3002<strong><a href=\"https:\/\/seeds.office.hiroshima-u.ac.jp\/profile\/ja.9750ed34c310fb91520e17560c007669.html\">\u5e83\u5cf6\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7<\/a><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a785dc e-flex e-con-boxed e-con e-parent\" data-id=\"6a785dc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5229db3 elementor-widget elementor-widget-heading\" data-id=\"5229db3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d81447c e-flex e-con-boxed e-con e-parent\" data-id=\"d81447c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03d64d1 e-con-full e-flex e-con e-child\" data-id=\"03d64d1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-84fc846 elementor-widget elementor-widget-image\" data-id=\"84fc846\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"567\" height=\"430\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4.jpg\" class=\"attachment-large size-large wp-image-180\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4.jpg 567w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/665c963e2a13f322adbd88e4-300x228.jpg 300w\" sizes=\"(max-width: 567px) 100vw, 567px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26d8abf e-con-full e-flex e-con e-child\" data-id=\"26d8abf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4d69a0d e-con-full e-flex e-con e-child\" data-id=\"4d69a0d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a99b18f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"a99b18f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma. Ando T (corresponding author), Okamoto K, Sato K, Goto Y, Izumi H, Kataoka N, Ueda Y, Kobayashi Y, Omachi K, Maeda Y, Furusho H, Iglesias-Bartolome R, Yoshimoto T, Shintani T, Yanamoto S, Miyauchi M, Gutkind JS, Kajiya M. Communications Biology, 9:1342, 2026<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-030f17c elementor-widget elementor-widget-text-editor\" data-id=\"030f17c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u304c\u3093\u306f\u5897\u6b96\u80fd\u3092\u9ad8\u3081\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5468\u56f2\u306e\u514d\u75ab\u7d30\u80de\u304b\u3089\u306e\u653b\u6483\u3092\u9003\u308c\u3066\u5897\u6b96\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3092\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3068\u8a00\u3044\u307e\u3059\u3002\u3000\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u3001\u304c\u3093\u7d30\u80de\u306e\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3068\u3057\u3066\u81e8\u5e8a\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<span style=\"text-wrap-mode: initial;\">\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066YAP\/TAZ\u306f\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3057\u3066\u304a\u308a\u3001\u5897\u6b96\u30fb\u85ac\u5264\u8010\u6027\u306b\u91cd\u8981\u306a\u3053\u3068\u306f\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u514d\u75ab\u56de\u907f\u306b\u95a2\u9023\u3059\u308b\u304b\u306f\u672a\u89e3\u660e\u3067\u3057\u305f\u3002<\/span><\/h4><h4>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001Hippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3059\u308b\u60a3\u8005\u304c\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u594f\u529f\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u4e00\u56e0\u3068\u3057\u3066\u3001YAP\/TAZ\u6d3b\u6027\u5316\u306f\u5206\u5316\u306e\u4f4e\u4e0b\u3068\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u6027\u4ea2\u9032\u3092\u793a\u3057\u3001\u7d50\u679c\u7684\u306b\u907a\u4f1d\u5b50\u5909\u7570\u91cf\uff08TMB\uff09\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u304b\u3089\u306e\u653b\u6483\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001YAP\/TAZ\u6d3b\u6027\u5316\u306f\u3001BRD4\u3068\u5171\u306bsuper enhancer\u306e\u5f62\u6210\u3092\u4ecb\u3057\u3066PD-L2\u306e\u767a\u73fe\u91cf\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3001\u514d\u75ab\u56de\u907f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u6a5f\u69cb\u304c\u3001\u7d50\u679c\u7684\u306b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3078\u306e\u611f\u53d7\u6027\u3092\u4ea2\u9032\u3055\u305b\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/h4><h4>\u3000\u4eca\u5f8c\u3001\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306b\u5bfe\u3059\u308bYAP\/TAZ\u6d3b\u6027\u5316\u306e\u5f71\u97ff\u3092\u89e3\u660e\u3057\u3066\u3044\u304f\u3068\u3068\u3082\u306b\u3001PD-L2\u3084YAP\/TAZ\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u305f\u306a\u5275\u85ac\u958b\u767a\u30fb\u6cbb\u7642\u6cd5\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/doi.org\/10.1038\/s42003-026-11092-0\">\u8ad6\u6587\u306f\u3053\u3061\u3089<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-397e260 e-flex e-con-boxed e-con e-parent\" data-id=\"397e260\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c9bac2e e-con-full e-flex e-con e-child\" data-id=\"c9bac2e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-55a8063 e-con-full e-flex e-con e-child\" data-id=\"55a8063\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b59118 elementor-widget elementor-widget-heading\" data-id=\"7b59118\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">YAP\/TAZ interacts with RBM39 to confer resistance against indisulam. Ando T (corresponding author), Okamoto K, Ueda Y, Kataoka N, Shintani T, Yanamoto S, Miyauchi M, Kajiya M. Oncogenesis, 13(1):25, 2024<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1cd19aa elementor-widget elementor-widget-text-editor\" data-id=\"1cd19aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066YAP\/TAZ\u306f\u6d3b\u6027\u5316\u3057\u3066\u304a\u308a\u3001\u3000\u6838\u5185\u79fb\u884c\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u6838\u5185\u306b\u304a\u3044\u3066YAP\/TAZ\u304c\u3069\u306e\u3088\u3046\u306a\u56e0\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u304b\u3001\u305d\u306e\u5168\u8c8c\u306f\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u672c\u7814\u7a76\u3067\u306fYAP\u306e\u65b0\u305f\u306a\u6838\u5185\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u3092\u63a2\u7d22\u3057\u3001RBM39\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/h4><h4>\u3000RBM39\u306fRNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u8ee2\u5199\u56e0\u5b50\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u4ea2\u9032\u3057\u3001\u307e\u305fmRNA\u306e\u6b63\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002Indisulam\u306f\u30a2\u30ea\u30eb\u30b9\u30eb\u30db\u30f3\u30a2\u30df\u30c9\u306e\u4e00\u3064\u3067\u3059\u3002Indisulam\u306fRBM39\u3092\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u306b\u7d50\u5408\u3055\u305b\u3066\u3001\u5206\u89e3\u3055\u305b\u307e\u3059\u3002\u305d\u308c\u3086\u3048\u306b\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u304c\u751f\u3058\u3001\u7d30\u80de\u6b7b\u306b\u81f3\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u81e8\u5e8a\u6cbb\u9a13\u306b\u304a\u3044\u3066\u306f\u671f\u5f85\u307b\u3069\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u305a\u3001\u8010\u6027\u6a5f\u69cb\u306e\u89e3\u660e\u304c\u671b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001Indisulam\u306f\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u306e\u7523\u751f\u3082\u4fc3\u3057\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5c06\u6765\u7684\u306a\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3084\u306f\u308a\u8010\u6027\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u306a\u3044\u9650\u308a\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3068\u306e\u4f75\u7528\u52b9\u679c\u3082\u9650\u5c40\u7684\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002<\/h4><h4>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001YAP\u304cRBM39\u306b\u7d50\u5408\u3057\u30011) YAP\/TAZ\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u3059\u3053\u3068\u30012) indisulam\u306b\u3088\u308bRBM39\u306e\u5206\u89e3\u3092\u59a8\u3052\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002YAP\/TAZ\u306e\u6d3b\u6027\u5316\u306fintegrin\/collagen\u306e\u7523\u751f\u3092\u4fc3\u3057\u3066FAK\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u307e\u305f\u7d30\u80de\u5468\u671f\u3084DNA\u4ee3\u8b1d\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3082\u963b\u5bb3\u3067\u304d\u308b\u305f\u3081\u3001indisulam\u3078\u306e\u8010\u6027\u3092\u4ed8\u4e0e\u3059\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/h4><h4>\u3000\u591a\u304f\u306e\u56fa\u5f62\u304c\u3093\u3067YAP\/TAZ\u306e\u6d3b\u6027\u5316\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001Indisulam\u304c\u6cbb\u9a13\u3067\u594f\u529f\u3057\u306b\u304f\u304b\u3063\u305f\u7406\u7531\u304c\u5206\u304b\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066RBM39\u3068YAP\/TAZ\u76f8\u4e92\u4f5c\u7528\u3092\u56de\u907f\u3067\u304d\u308b\u3088\u3046\u306a\u65b0\u305f\u306a\u5275\u85ac\u306e\u958b\u767a\u304c\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s41389-024-00527-0\" target=\"_blank\" rel=\"noopener\">DOI: 10.1038\/s41389-024-00527-0<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d332071 elementor-widget elementor-widget-image\" data-id=\"d332071\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"520\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-1024x520.jpg\" class=\"attachment-large size-large wp-image-177\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-1024x520.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-300x152.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64-768x390.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6694c60ff9001326978a0f64.jpg 1055w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e15ef35 e-flex e-con-boxed e-con e-parent\" data-id=\"e15ef35\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4344279 e-con-full e-flex e-con e-child\" data-id=\"4344279\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e438aac elementor-widget elementor-widget-image\" data-id=\"e438aac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"513\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1024x513.jpg\" class=\"attachment-large size-large wp-image-176\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1024x513.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-300x150.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-768x385.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96-1536x770.jpg 1536w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/65202d842855cb2314f8eb96.jpg 2000w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2234010 e-con-full e-flex e-con e-child\" data-id=\"2234010\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4303de4 e-con-full e-flex e-con e-child\" data-id=\"4303de4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c265d25 elementor-widget elementor-widget-heading\" data-id=\"c265d25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">AXL activates YAP through the EGFR\u2013LATS1\/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, Okamoto K, Ando T (corresponding author), Izumi H, Kobayashi SS, Shintani T, Gutkind JS, Yanamoto S, Miyauchi M, Kajiya M. Oncogene, 42:2869-2877, 2023.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e46376 elementor-widget elementor-widget-text-editor\" data-id=\"3e46376\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>\u53d7\u5bb9\u4f53\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306eEGFR\u306fYAP\u3092\u6d3b\u6027\u5316\u3055\u305b<span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u307e\u3059\u304c\u3001EGFR\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u304c\u9650\u5b9a\u7684\u306a\u306e\u306f\u306a\u305c\u3067\u3057\u3087<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3046\u304b\u3002EGFR\u963b\u5bb3\u85ac\u306b\u8010\u6027\u3092\u793a\u3059\u75c7\u4f8b\u3067YAP\u306e\u518d\u6d3b\u6027\u5316\u304c<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u751f\u3058\u308b\u3053\u3068\u304b\u3089\u3001\u5225\u306e\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304c\u95a2\u4e0e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u89e3\u6790\u304b\u3089\u65b0\u305f\u306bAXL<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002AXL\u306fEGFR\u3068\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">EGFR-LATS1\/2\u3092\u4ecb\u3057\u3066YAP\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u6a5f\u69cb\u3092\u660e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">EGFR\u963b\u5bb3\u85ac\u306e\u8010\u6027\u3092\u89e3\u9664\u3059\u308b\u305f\u3081\u3001<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">AXL\u963b\u5bb3\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e<\/span><span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u3057\u305f\u3002<\/span><\/h4><h4>\u3000EGFR\u963b\u5bb3\u85ac\u3068AXL\u963b\u5bb3\u85ac\u306e\u4f75\u7528\u3001\u3042\u308b\u3044\u306f\u65b0\u305f\u306a\u6cbb<span style=\"letter-spacing: -0.1px; text-wrap-mode: initial;\">\u7642\u6226\u7565\u306e\u958b\u767a\u304c\u4eca\u5f8c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/span><\/h4><h4>Readers\u00a0Choice: The best of Oncogene 2023\u306b\u9078\u3070\u308c\u307e\u3057\u305f\uff082024\u5e741\u67089\u65e5\uff09\uff01<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s41388-023-02810-7\" target=\"_blank\" rel=\"noopener\">DOI: 10.1038\/s41388-023-02810-7<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a1bc7d e-flex e-con-boxed e-con e-parent\" data-id=\"6a1bc7d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b2d382a e-con-full e-flex e-con e-child\" data-id=\"b2d382a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-244b563 e-con-full e-flex e-con e-child\" data-id=\"244b563\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8f446f8 elementor-widget elementor-widget-heading\" data-id=\"8f446f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS. Communications Biology, 4:1237, 2021.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f9ac38 elementor-widget elementor-widget-text-editor\" data-id=\"5f9ac38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"font-weight: 400;\">\u53d7\u5bb9\u4f53\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306eEGFR\u306f\u30ea\u30ac\u30f3\u30c9EGF\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3057\u3001\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u5897\u6b96\u3092\u4fc3\u3057\u307e\u3059\u3002\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u306f\u907a\u4f1d\u5b50\u5897\u5e45\u30fb\u904e\u5270\u767a\u73fe\u3057\u3001\u80ba\u817a\u764c\u3067\u306f\u304a\u3088\u305d50%\u304c\u6d3b\u6027\u5316\u5909\u7570\u3092\u793a\u3057\u307e\u3059\u3002EGFR\u3068YAP\/TAZ\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u8a73\u7d30\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u672c\u8ad6\u6587\u3067\u306f\u3001EGFR\u304cHippo\u69cb\u6210\u8981\u7d20\u306e\u4e00\u3064\u3067\u3042\u308b<\/h4><h4 style=\"font-weight: 400;\">MOB1\u306e3\u7b87\u6240\u306e\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u306e\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u3059\u3053\u3068\u3067\u3001LATS1\/2\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001YAP\/TAZ\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u3059\u6a5f\u69cb\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u89e3\u660e\u3057\u307e\u3057\u305f\u3002<\/h4><h4 style=\"font-weight: 400;\">\u3000\u6b74\u53f2\u7684\u306b\u6614\u304b\u3089\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u305fEGFR\u304c\u3001\u307e\u3060\u767a\u898b\u3055\u308c\u3066\u304b\u3089\u6b74\u53f2\u7684\u306b\u6d45\u3044\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3067\u3042\u308bHippo\u7d4c\u8def\u3092\u5236\u5fa1\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u70b9\u304c\u4eca\u56de\u306e\u30b7\u30b0\u30ca\u30eb\u7814\u7a76\u3068\u3057\u3066\u306e\u9762\u767d\u3055\u3068\u30a4\u30f3\u30d1\u30af\u30c8\u306e\u5927\u304d\u3055\u3092\u8c61\u5fb4\u3057\u3066\u3044\u307e\u3059\u3002<\/h4><h4><a href=\"https:\/\/www.nature.com\/articles\/s42003-021-02744-4\">DOI: 10.1038\/s42003-021-02744-4<\/a><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-164a71a elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"164a71a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"346\" height=\"222\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2.jpg\" class=\"attachment-large size-large wp-image-179\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2.jpg 346w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/6526b58497b26e23c1e25eb2-300x192.jpg 300w\" sizes=\"(max-width: 346px) 100vw, 346px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u5ba4\u306e\u5168\u3066\u306e\u8ad6\u6587\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u306e\u30ea\u30f3\u30af\u304b\u3089\u3054\u78ba\u8a8d\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u5e83\u5cf6\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7 \u7814\u7a76\u696d\u7e3e\uff08\u8ad6\u6587\u7d39\u4ecb\uff09 Dysregulation of the Hippo pathway enhances PD-L2 transc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-165","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/comments?post=165"}],"version-history":[{"count":50,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165\/revisions"}],"predecessor-version":[{"id":1139,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/165\/revisions\/1139"}],"wp:attachment":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/media?parent=165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}