{"id":268,"date":"2025-07-19T10:14:04","date_gmt":"2025-07-19T10:14:04","guid":{"rendered":"https:\/\/oralpathology.hiroshima-u.ac.jp\/?page_id=268"},"modified":"2025-07-29T15:12:57","modified_gmt":"2025-07-29T15:12:57","slug":"research-jp","status":"publish","type":"page","link":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/research-jp\/","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"268\" class=\"elementor elementor-268\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d966f32 e-flex e-con-boxed e-con e-parent\" data-id=\"d966f32\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aaaf460 elementor-widget elementor-widget-heading\" data-id=\"aaaf460\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u7d39\u4ecb<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0561db0 e-flex e-con-boxed e-con e-parent\" data-id=\"0561db0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-92043e0 elementor-widget elementor-widget-text-editor\" data-id=\"92043e0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"video-hero-wrapper\">\n  <video id=\"bg-video\" autoplay loop muted playsinline>\n    <source src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/iStock-2202842849.mp4\" type=\"video\/mp4\" \/>\n    \u304a\u4f7f\u3044\u306e\u30d6\u30e9\u30a6\u30b6\u3067\u306f\u52d5\u753b\u304c\u518d\u751f\u3067\u304d\u307e\u305b\u3093\u3002\n  <\/video>\n  <div class=\"video-text-overlay\">\n    <h2>Genetic alterations and cell signaling research<\/h2>\n  <\/div>\n<\/div>\n\n<style>\nbody, html {\n  margin: 0;\n  padding: 0;\n}\n\n.video-hero-wrapper {\n  position: relative;\n  width: 100vw;\n  height: 600px;\n  overflow: hidden;\n  z-index: 1;\n  margin-left: calc(-50vw + 50%);\n}\n\n#bg-video {\n  position: absolute;\n  top: 50%;\n  left: 50%;\n  min-width: 100%;\n  min-height: 100%;\n  transform: translate(-50%, -50%);\n  object-fit: cover;\n  z-index: -1;\n}\n\n.video-text-overlay {\n  position: absolute;\n  bottom: 30px;   \/* \u4e0b\u304b\u3089\u306e\u8ddd\u96e2 *\/\n  left: 30px;     \/* \u5de6\u304b\u3089\u306e\u8ddd\u96e2 *\/\n  color: white;\n  font-size: 1.8rem;\n  text-align: left;\n  z-index: 2;\n  text-shadow: 0 0 10px rgba(0,0,0,0.7);\n}\n<\/style>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8baac3f e-flex e-con-boxed e-con e-parent\" data-id=\"8baac3f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-17619c6 elementor-widget elementor-widget-heading\" data-id=\"17619c6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u304c\u3093\u3092\u7406\u89e3\u3059\u308b<br>\n\u301c\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u306a\u305c\u91cd\u8981\u304b\u301c<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cee479f e-flex e-con-boxed e-con e-parent\" data-id=\"cee479f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f9aada elementor-widget elementor-widget-text-editor\" data-id=\"6f9aada\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u7d30\u80de\u5185\u3067\u306f\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u6b63\u5e38\u306e\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u5916\u304b\u3089\u306e\u751f\u5b58\u30b7\u30b0\u30ca\u30eb\uff08\u4f8b\u3048\u3070\u30ea\u30ac\u30f3\u30c9\uff09\u3092\u53d7\u5bb9\u4f53\u304c\u53d7\u3051\u53d6\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5185\u306e\u5206\u5b50\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u3066\u6d3b\u6027\u5316\u3057\u3001\u3055\u3089\u306b\u6b21\u306e\u5206\u5b50\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u9023\u7d9a\u7684\u306b\u523a\u6fc0\u3092\u4f1d\u3048\u3066\u3044\u304d\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u306f\u5897\u6b96\u30fb\u751f\u5b58\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u5897\u6b96\u304c\u4ea2\u9032\u3057\u307e\u3059\u3002\u7279\u306b\u304c\u3093\u3067\u306f\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u30fb\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u3066\u304a\u308a\u3001\u7570\u5e38\u306a\u5897\u6b96\u304c\u751f\u3058\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u5927\u5143\u3068\u306a\u308b\u306e\u306f\u300c<b>\u907a\u4f1d\u5b50\u7570\u5e38<\/b>\u300d\u3067\u3059\u3002\u304c\u3093\u3067\u306f\u907a\u4f1d\u5b50\u7570\u5e38\uff08\u5909\u7570\u3001\u5897\u5e45\u3001\u6b20\u5931\u3001\u878d\u5408\u907a\u4f1d\u5b50\u306a\u3069\uff09\u304c\u751f\u3058\u308b\u3053\u3068\u3067\u3001\u5897\u6b96\u3092\u4fc3\u3059\u907a\u4f1d\u5b50\uff08\u304c\u3093\u907a\u4f1d\u5b50\uff09\u306e\u6d3b\u6027\u5316\u3001\u5897\u6b96\u3092\u666e\u6bb5\u306f\u6291\u5236\u3057\u3066\u3044\u308b\u306f\u305a\u306e\u907a\u4f1d\u5b50\uff08\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\uff09\u306e\u4e0d\u6d3b\u6027\u5316\u304c\u751f\u3058\u308b\u3053\u3068\u3067\u3001\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u7570\u5e38\u304c\u751f\u3058\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u4e2d\u306b\u306f\u3042\u307e\u308a\u5897\u6b96\u30fb\u751f\u5b58\u306b\u95a2\u4fc2\u306e\u306a\u3044\u3082\u306e\u3082\u3042\u308a\u307e\u3059\uff08\u30d1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\u5909\u7570\uff09\u3001\u4e00\u65b9\u3067\u5897\u6b96\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u3082\u306e\uff08<b>\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570<\/b>\uff09\u3082\u3042\u308a\u307e\u3059\u3002\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u304a\u3088\u3073\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u6b63\u5e38\u7d30\u80de\u306b\u306f\u3067\u304d\u308b\u3060\u3051\u5f71\u97ff\u3092\u4e0e\u3048\u305a\u3001\u304c\u3093\u7d30\u80de\u3060\u3051\u653b\u6483\u3067\u304d\u308b\u85ac\u5264\u304c\u3067\u304d\u306a\u3044\u304b\uff1f\u305d\u306e\u8003\u3048\u306b\u57fa\u3065\u3044\u3066\u767b\u5834\u3057\u305f\u3082\u306e\u304c\u300c\u5206\u5b50\u6a19\u7684\u85ac\u300d\u3068\u306a\u308a\u307e\u3059\u3002\u4eca\u3067\u306f\u591a\u304f\u306e\u5206\u5b50\u6a19\u7684\u85ac\u304c\u767b\u5834\u3057\u3001\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u6cbb\u7642\u85ac\u306b\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u8fd1\u5e74\u767b\u5834\u3057\u305f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u3001\u304c\u3093\u7d30\u80de\u306b\u3088\u308b\u514d\u75ab\u7d30\u80de\u306e\u6291\u5236\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6a19\u7684\u3068\u3057\u305f\u5206\u5b50\u6a19\u7684\u85ac\u306e\u4e00\u3064\u3068\u8a00\u3048\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u304c\u3093\u7d30\u80de\u306e\u767a\u73fe\u3059\u308bPD-L1\u3068T\u7d30\u80de\u306e\u767a\u73fe\u3059\u308bPD-1\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u3059\u3053\u3068\u3067\u6297\u816b\u760d\u52b9\u679c\u304c\u5f97\u3089\u308c\u307e\u3059\u3002\u53e3\u8154\u30fb\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u306f\u907a\u4f1d\u5b50\u5897\u5e45\u30fb\u904e\u5270\u767a\u73fe\u3057\u3066\u3044\u308bEGFR\u3092\u6a19\u7684\u3068\u3057\u305fCetuximab\uff08\u6297EGFR\u6297\u4f53\uff09\u304c\u627f\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3068\u3057\u3066\u306fNivolumab, Pembrolizumab\u306e2\u7a2e\u985e\u306e\u6297PD-1\u6297\u4f53\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3000\u3055\u3089\u306b2019\u5e74\u304b\u3089\u306f\u65e5\u672c\u5168\u56fd\u3067<b>\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642<\/b>\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002\u6b21\u4e16\u4ee3\u30b7\u30fc\u30af\u30a8\u30f3\u30b5\u30fc\u3092\u7528\u3044\u3066\u304c\u3093\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u3092\u793a\u3059\u5206\u5b50\u3042\u308b\u3044\u306f\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u963b\u5bb3\u3059\u308b\u5206\u5b50\u6a19\u7684\u85ac\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u306e\u9078\u629e\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306f\u5206\u5b50\u6a19\u7684\u85ac\u306e\u9078\u629e\u306b\u306f\u81d3\u5668\u306b\u3088\u308b\u58c1\u304c\u5b58\u5728\u3057\u3066\u304a\u308a\u3001\u304c\u3093\u304c\u767a\u751f\u3057\u305f\u81d3\u5668\u306b\u304a\u3044\u3066\u627f\u8a8d\u3055\u308c\u305f\u85ac\u5264\u3057\u304b\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306f\u81d3\u5668\u6bce\u306e\u58c1\u3092\u4f4e\u304f\u3057\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u57fa\u3065\u3044\u3066\u6cbb\u7642\u3092\u9078\u629e\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<b>Precision medicine<\/b>\u306b\u8fd1\u3065\u3044\u3066\u3044\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<p>\u3000\u3057\u304b\u3057\u306a\u304c\u3089\u3001<b>\u554f\u984c\u70b9\u304c\u4e00\u3064\u3042\u308a\u307e\u3059<\/b>\u3002<u>\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u7279\u5b9a\u3057\u3066\u3082\u3001\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u5341\u5206\u306b\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u5206\u5b50\u6a19\u7684\u85ac\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u306a\u3051\u308c\u3070\u3001\u6cbb\u7642\u306b\u7d50\u3073\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093<\/u>\u3002<\/p>\n<p>\u3000\u3060\u304b\u3089\u3053\u305d\u3001\u3069\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3001\u3069\u306e\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u3053\u308c\u3092\u8a73\u7d30\u306b\u7814\u7a76\u3057\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u975e\u5e38\u306b\u91cd\u8981\u306a\u306e\u3067\u3059\u3002\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u7570\u5e38\u3092\u7e4b\u3050\u7814\u7a76\u304c\u3042\u3063\u3066\u3053\u305d\u3001\u5c06\u6765\u306e\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u7e4b\u304c\u308a\u3001\u6700\u7d42\u7684\u306a\u60a3\u8005\u3078\u306e\u6cbb\u7642\u306b\u7e4b\u304c\u308a\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d3b7f4e e-flex e-con-boxed e-con e-parent\" data-id=\"d3b7f4e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea3904a elementor-widget elementor-widget-heading\" data-id=\"ea3904a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066\u6975\u3081\u3066\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def<br>\n\u301cHippo\u7d4c\u8def\u3068YAP\/TAZ\u3068\u306f\u301c<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48c912e e-flex e-con-boxed e-con e-parent\" data-id=\"48c912e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adfa2c0 elementor-widget__width-inherit elementor-widget elementor-widget-image\" data-id=\"adfa2c0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"546\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386-1024x546.jpg\" class=\"attachment-large size-large wp-image-264\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386-1024x546.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386-300x160.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386-768x410.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386-1536x819.jpg 1536w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653a03e66ddf492197636386.jpg 2000w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">\u5f15\u7528\u5143\uff1aIntegrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine. Ando T et al, J Pers Med, 12(10):1544, 2022. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-413258d e-flex e-con-boxed e-con e-parent\" data-id=\"413258d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bab114b elementor-widget elementor-widget-text-editor\" data-id=\"bab114b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u3000Hippo\u7d4c\u8def\u306f\u3001\u7d30\u80de\u306e\u5897\u6b96\u3001\u7d44\u7e54\u30fb\u81d3\u5668\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u62c5\u3046\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3067\u3059\u3002Hippo\u7d4c\u8def\u306f\u4e3b\u306bmammalian STE20-like kinase 1 and 2 (MST1\/2) \u3068large tumor suppressor 1 and 2 (LATS1\/2) \u306e\u30bb\u30ea\u30f3\u30fb\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3068\u3001\u305d\u308c\u305e\u308c\u306e\u30a2\u30c0\u30d7\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u3067\u3042\u308bsalvador homolog 1 (SAV1) \u3068MOB kinase activators 1A and 1B (MOB1A\/B) \u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002Hippo\u7d4c\u8def\u306e\u4e0b\u6d41\u306b\u306fYes-associated protein (YAP) \u3068transcriptional co-activator with PDZ binding motif (TAZ) \u304c\u4f4d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002Hippo\u7d4c\u8def\u304c\u6d3b\u6027\u5316\u3059\u308b\u969b\u306b\u306f\u3001LATS1\/2\u304cYAP\/TAZ\u306e5\u7b87\u6240\u306e\u30bb\u30ea\u30f3\u6b8b\u57fa\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u8cea\u5185\u5c40\u5728\u3042\u308b\u3044\u306f\u30e6\u30d3\u30ad\u30c1\u30f3\u30fb\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306b\u3088\u308b\u5206\u89e3\u3078\u3068\u8a98\u5c0e\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001Hippo\u7d4c\u8def\u304c\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u969b\u306b\u306f\u3001\u8131\u30ea\u30f3\u9178\u5316\u3055\u308c\u305fYAP\/TAZ\u304c\u6838\u5185\u306b\u79fb\u884c\u3057\u3066\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bTEA domain family members (TEAD) \u3068\u7d50\u5408\u3057\u3001\u5171\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u3067\u3001connective growth factor (CTGF) \u3084cysteine-rich angiogenic inducer 61 (CYR61) \u306a\u3069\u5897\u6b96\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4ea2\u9032\u3057\u307e\u3059\u3002Hippo\u7d4c\u8def\u3068YAP\/TAZ\u306f\u3001\u7d30\u80de\u5bc6\u5ea6\u3001\u30e1\u30ab\u30cb\u30ab\u30eb\u30b9\u30c8\u30ec\u30b9\u3001\u8840\u6e05\u306a\u3069\u306e\u751f\u7406\u7684\u6761\u4ef6\u4e0b\u306b\u304a\u3044\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305fGPCR\u3001\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306a\u3069\u3082\u4e0a\u6d41\u56e0\u5b50\u3068\u3057\u3066\u5236\u5fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3ed390e e-flex e-con-boxed e-con e-parent\" data-id=\"3ed390e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-295448e elementor-widget elementor-widget-heading\" data-id=\"295448e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3051\u308bHippo\u7d4c\u8def\u306e\u610f\u7fa9\u3068\u306f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0424682 e-flex e-con-boxed e-con e-parent\" data-id=\"0424682\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d95610c elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"d95610c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"772\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/666315845c7fa828544178c1-1024x772.jpg\" class=\"attachment-large size-large wp-image-171\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/666315845c7fa828544178c1-1024x772.jpg 1024w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/666315845c7fa828544178c1-300x226.jpg 300w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/666315845c7fa828544178c1-768x579.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/666315845c7fa828544178c1.jpg 1296w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73dc9eb elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"73dc9eb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u79c1\u305f\u3061\u306f\u3001\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066\u69d8\u3005\u306a\u907a\u4f1d\u5b50\u7570\u5e38\u304cHippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u306b\u3088\u308bYAP\/TAZ\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p><p>\u3000Tissue inhibitor of metalloproteinase-1 (TIMP-1) \u304c\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3044\u3066\u904e\u5270\u767a\u73fe\u3057\u3066\u304a\u308a\u3001CD63\/Integrin\u3092\u4ecb\u3057\u3066YAP\/TAZ\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u5897\u6b96\u3092\u4fc3\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Ando T et al, Oncogene, 2017\uff09\u3002<\/p><p>\u3000Epidermal Growth Factor Receptor (EGFR) \u306f\u3001\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bEGF\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u30db\u30e2\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3001\u81ea\u5df1\u30ea\u30f3\u9178\u5316\u3057\u3066\u4e0b\u6d41\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u5897\u6b96\u3092\u4fc3\u3057\u307e\u3059\u3002EGFR\u306f\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u306f\u907a\u4f1d\u5b50\u5897\u5e45\u30fb\u904e\u5270\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002EGFR\u306fMOB1\u306e3\u7b87\u6240\u306e\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u306e\u30ea\u30f3\u9178\u5316\u3092\u4fc3\u3059\u3053\u3068\u3067\u3001LATS1\/2\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3001YAP\/TAZ\u3092\u6d3b\u6027\u5316\u3055\u305b\u3066\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08<a class=\"hover-underline\" href=\"https:\/\/doi.org\/10.1038\/s42003-021-02744-4\" target=\"_blank\" rel=\"noopener\">Ando T et al, Commun Biol, 2021<\/a>\uff09\u3002<\/p><p>\u3000EGFR\u963b\u5bb3\u85ac\u306f\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u5206\u5b50\u6a19\u7684\u85ac\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u594f\u529f\u7387\u306f\u4f4e\u304f\u3001\u8010\u6027\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u8010\u6027\u306b\u306f\u5225\u306e\u53d7\u5bb9\u4f53\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff08RTK\uff09\u306e\u9ad8\u767a\u73fe\u3084YAP\u518d\u6d3b\u6027\u5316\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u78ba\u304b\u306bEGFR\u963b\u5bb3\u85ac\u306f\u4e00\u904e\u6027\u306bYAP\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3046\u308b\u304c\u3001\u4f55\u3089\u304b\u306eRTK\u304c\u9ad8\u767a\u73fe\u3057\u3001YAP\u306e\u518d\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u8010\u6027\u7372\u5f97\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u306e\u65b0\u305f\u306aRTK\u3068\u3057\u3066AXL\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002AXL\u306fEGFR-LATS1\/2\u3092\u4ecb\u3057\u3066YAP\u3092\u6d3b\u6027\u5316\u3055\u305b\u307e\u3059\u3002EGFR\u963b\u5bb3\u85ac\u306bAXL\u963b\u5bb3\u85ac\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001YAP\u306e\u5f37\u529b\u306a\u4e0d\u6d3b\u6027\u5316\u3068\u5897\u6b96\u6291\u5236\u3092\u5c0e\u304f\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3088\u3063\u3066\u3001\u5c06\u6765\u7684\u306bEGFR\u963b\u5bb3\u85ac\u3068AXL\u963b\u5bb3\u85ac\u306e\u4f75\u7528\u3001\u3042\u308b\u3044\u306fYAP\u6a19\u7684\u85ac\u3092\u7528\u3044\u305f\u6cbb\u7642\u6cd5\u958b\u767a\u306e\u91cd\u8981\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Okamoto K et al, Oncogene, 2023\uff09\u3002<\/p><p>\u3000YAP\/TAZ\u306f\u6d3b\u6027\u5316\u3057\u3066\u6838\u5185\u306b\u79fb\u884c\u3057\u305f\u5f8c\u3082\u3001\u3055\u3089\u306b\u6838\u5185\u56e0\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u3067\u306e\u7279\u6709\u306e\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u3001RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u306e\u4e00\u3064\u3067\u3042\u308bRBM39\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002RBM39\u306fYAP\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067YAP\/TEAD\u306e\u8ee2\u5199\u6d3b\u6027\u3092\u4ea2\u9032\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001indisulam\u3068\u3044\u3046RBM39\u306e\u5206\u89e3\u3092\u4fc3\u3059\u85ac\u5264\u306f\u3001RBM39\u3092\u5206\u89e3\u3055\u305b\u308b\u3053\u3068\u3067\u8ee2\u5199\u6d3b\u6027\u306e\u4f4e\u4e0b\u3068\u3068\u3082\u306b\u3001\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3092\u8a98\u5c0e\u3057\u3066\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001YAP\u304cRBM39\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001indisulam\u306e\u5206\u89e3\u304c\u9045\u5ef6\u3057\u3001\u8ee2\u5199\u6d3b\u6027\u306e\u4f4e\u4e0b\u304c\u751f\u3058\u305a\u3001\u307e\u305f\u7570\u5e38\u306a\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8a98\u5c0e\u3082\u751f\u3058\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3064\u307e\u308a\u3001YAP\u3068RBM39\u306findisulam\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u4ed8\u4e0e\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u76f8\u4e92\u4f5c\u7528\u90e8\u4f4d\u306e\u89e3\u6790\u3092\u9032\u3081\u3066\u3001\u76f8\u4e92\u4f5c\u7528\u3092\u6a19\u7684\u3068\u3057\u305f\u5275\u85ac\u958b\u767a\u306b\u3064\u306a\u3052\u3066\u3044\u304d\u307e\u3059\uff08Ando T et al, Oncogenesis (under revision), 2024)\u3002<\/p><p>\u3000\u304c\u3093\u7d30\u80de\u304c\u5897\u6b96\u3059\u308b\u305f\u3081\u306b\u306f\u514d\u75ab\u7d30\u80de\u304b\u3089\u306e\u653b\u6483\u3092\u9632\u3050\u3042\u308b\u3044\u306f\u56de\u907f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\uff08\u514d\u75ab\u56de\u907f\uff09\u3002\u304c\u3093\u7d30\u80de\u306f\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3059\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u5909\u7570\u91cf\uff08TMB\uff09\u304c\u9ad8\u3044\u307b\u3069\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\u3092\u7523\u751f\u3057\u3001\u7d30\u80de\u969c\u5bb3\u6027 T\u7d30\u80de\u304b\u3089\u306e\u653b\u6483\u3092\u53d7\u3051\u307e\u3059\u304c\u3001PD-L1\u3092\u767a\u73fe\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u306ePD-1\u3092\u4ecb\u3057\u3066\u4e0d\u6d3b\u6027\u5316\u3055\u305b\u3001\u514d\u75ab\u56de\u907f\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001Hippo\u7d4c\u8def\u3068\u514d\u75ab\u56de\u907f\u6a5f\u69cb\u306e\u95a2\u9023\u306e\u8a73\u7d30\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u79c1\u306f\u3001Hippo\u7d4c\u8def\u306b\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3059\u308b\u60a3\u8005\u306f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\uff08\u6297PD-1\u6297\u4f53\uff09\u3078\u306e\u611f\u53d7\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002YAP\/TAZ\u6d3b\u6027\u5316\u306f\u304c\u3093\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u4e0d\u5b89\u5b9a\u6027\u3092\u60f9\u8d77\u3059\u308b\u3053\u3068\u3067TMB\u3092\u5897\u52a0\u3055\u305b\u3066\u3001\u7d30\u80de\u969c\u5bb3\u6027T\u7d30\u80de\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001YAP\/TAZ\u306fPD-L2\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u56de\u907f\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u304c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3078\u306e\u611f\u53d7\u6027\u4ea2\u9032\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4eca\u5f8c\u3001\u3055\u3089\u306b\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u3078\u306e\u5f71\u97ff\u3092\u63a2\u7d22\u3057\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\uff08Ando T et al, under review, 2025) \u3002<\/p><p>\u3000\u4ee5\u4e0a\u306e\u3088\u3046\u306b\u3001Hippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5c0e\u304f\u907a\u4f1d\u5b50\u7570\u5e38\u306f\u89e3\u660e\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u304c\u3001\u5168\u8c8c\u89e3\u660e\u306e\u305f\u3081\u306b\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3ad7d2c e-flex e-con-boxed e-con e-parent\" data-id=\"3ad7d2c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-02e1ad5 elementor-widget elementor-widget-heading\" data-id=\"02e1ad5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Hippo-YAP\/TAZ\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u305f\u53e3\u8154\u304c\u3093\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u5411\u3051\u3066<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f9dcab8 e-flex e-con-boxed e-con e-parent\" data-id=\"f9dcab8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d722914 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"d722914\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"949\" height=\"1024\" src=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-949x1024.jpg\" class=\"attachment-large size-large wp-image-266\" alt=\"\" srcset=\"https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-949x1024.jpg 949w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-278x300.jpg 278w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-768x828.jpg 768w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-1424x1536.jpg 1424w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1-1899x2048.jpg 1899w, https:\/\/oralpathology.hiroshima-u.ac.jp\/wp-content\/uploads\/2025\/07\/653dfc1d26c02221e816f8ed-1.jpg 2000w\" sizes=\"(max-width: 949px) 100vw, 949px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">\u5f15\u7528\u5143\uff1aIntegrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine. Ando T et al, J Pers Med, 12(10):1544, 2022. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-596612d e-flex e-con-boxed e-con e-parent\" data-id=\"596612d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33b01df elementor-widget elementor-widget-text-editor\" data-id=\"33b01df\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u3000\u3069\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u7570\u5e38\u304cHippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5c0e\u304f\u304b\u3001\u3053\u306e\u8a73\u7d30\u306a\u6a5f\u69cb\u306e\u5168\u8c8c\u306f\u6b8b\u5ff5\u306a\u304c\u3089\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u3000\u3057\u305f\u304c\u3063\u3066\u3001\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u3067\u5f97\u3089\u308c\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u4e2d\u306b\u306f\u3001Hippo-YAP\/TAZ\u7d4c\u8def\u306e\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u305f\u3081\u6cbb\u7642\u306b\u7d50\u3073\u3064\u304b\u306a\u3044\u3082\u306e\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305fHippo\u7d4c\u8def\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5c0e\u304f\u3068\u5206\u304b\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u540c\u5b9a\u3067\u304d\u305f\u3068\u3057\u3066\u3082\u3001\u73fe\u72b6\u3067\u306fHippo-YAP\/TAZ\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u85ac\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u6709\u529b\u306a\u5019\u88dc\u3068\u3057\u3066\u306f\u3001TEAD\u963b\u5bb3\u85ac\u304c\u3042\u308a\u307e\u3059\u3002YAP\/TEAD\u306e\u7d50\u5408\u90e8\u4f4d\u304c\u540c\u5b9a\u3055\u308c\u3066\u3001TEAD\u306e\u30dd\u30b1\u30c3\u30c8\u306b\u5316\u5408\u7269\u304c\u5165\u308a\u8fbc\u307f\u3001\u4e21\u8005\u306e\u7d50\u5408\u3092\u89e3\u96e2\u3055\u305b\u307e\u3059\u3002<\/p>\n<p>\u3000\u79c1\u305f\u3061\u306f\u3001\u907a\u4f1d\u5b50\u7570\u5e38\u3068Hippo-YAP\/TAZ\u7d4c\u8def\u3092\u7e4b\u3050\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3001\u305d\u3057\u3066\u3055\u3089\u306bHippo-YAP\/TAZ\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u6b21\u4e16\u4ee3\u306e\u304c\u3093\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u85ac\u306e\u7814\u7a76\u958b\u767a\u306b\u73fe\u5728\u3082\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u7d39\u4ecb \u304a\u4f7f\u3044\u306e\u30d6\u30e9\u30a6\u30b6\u3067\u306f\u52d5\u753b\u304c\u518d\u751f\u3067\u304d\u307e\u305b\u3093\u3002 Genetic alterations and cell signaling research \u304c\u3093\u3092\u7406\u89e3\u3059\u308b \u301c\u907a\u4f1d\u5b50\u7570\u5e38\u3068\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u304c\u306a\u305c\u91cd\u8981\u304b\u301c \u7d30\u80de\u5185\u3067\u306f\u69d8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-268","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/comments?post=268"}],"version-history":[{"count":47,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/268\/revisions"}],"predecessor-version":[{"id":857,"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/pages\/268\/revisions\/857"}],"wp:attachment":[{"href":"https:\/\/oralpathology.hiroshima-u.ac.jp\/index.php\/wp-json\/wp\/v2\/media?parent=268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}